Embryo glue – does it work or not?

Embryo glue – does it work or not?

Does embryo glue (or, strictly speaking, EmbryoGlue) really work? We were initially sceptical. A low-cost product that helps your embryo to implant? It sounded too good to be true. Critics initially called embryo glue too simplistic. But has that view changed?

Today, embryo glue is used by many fertility clinics. There’s been updated research and positive feedback. It may benefit some patients more than others, but some results have been encouraging. We think embryo glue has promise.

Embryo glue isn’t really a glue at all. It’s a specially developed formula that contains, among other things, high levels of a substance called hyaluronan, also known as hyaluronic acid.

Hyaluronan occurs naturally in your uterine lining. It makes secretions stickier, aiding the very complex process of implantation. Embryo glue mimics those endometrial secretions. On your embryo transfer day, your embryos are first dipped into the glue. Its adhesive effect may help your embryos attach, enhancing implantation. Some linings need that extra push.

Like many fertility add-ons, embryo glue faced resistance. An early study in the Clinical and Experimental Obstetrics and Gynaecology cast doubt on its effects. That gave the makers of the product a very bad morning. Other reviews, and clinical reaction, have been mixed.

But more recent research suggests otherwise. A review carried out by the Cochrane Menstrual Disorders and Sub-Fertility Group, published in the respected Cochrane Database of Systematic Reviews, showed more promising results.

The evidence suggested that clinical pregnancy and live birth rates are improved by the use of hyaluronic acid. Other studies suggest embryo glue may be particularly beneficial for women with repeated implantation failure or unexplained infertility.

Fertility clinics are best placed to monitor implantation failure. So if you’ve had previous fertility treatments where it all looked promising – nice lining, good-quality embryos, normal uterine environment – and your treatment failed, EmbryoGlue might be needed.

Money-wise, embryo glue is a relatively low-cost fertility add-on. It’s not going to break the bank. Clinic fees are around £200. It’s non-contentious, so any patient can request it and clinics are unlikely to object.

Our thinking is this. If fertility clinics see value in an affordable product, backed by fairly reasonable research, perhaps patients should too. It’s certainly less controversial, and less invasive, than endometrial scratching.

Research into the benefits of embryo glue continues. But if you’ve had issues with implantation or repeat miscarriages, it’s worth considering. Speak to your clinic, and watch our video below.

27 Comments
  • Ginika
    Posted at 03:26h, 09 December Reply

    Can embryo glue be used on frozen embryos? Can I talk to my doctor or suggest to my doctor about it, since I have had several failed IVFs.

    • Your IVF Journey
      Posted at 07:18h, 09 December Reply

      Yes, embryo glue can be used on frozen embryos. Please speak to your fertility clinic about this and good luck with your FET.

    • Jennifer
      Posted at 20:49h, 12 December Reply

      I just used embryo glue on my frozen embryo.

  • Ginika
    Posted at 03:26h, 09 December Reply

    Can embryo glue be used on frozen embryos? Can I talk to my doctor or suggest to my doctor about it, since I have had several failed IVFs.

    • Your IVF Journey
      Posted at 07:18h, 09 December Reply

      Yes, embryo glue can be used on frozen embryos. Please speak to your fertility clinic about this and good luck with your FET.

    • Jennifer
      Posted at 20:49h, 12 December Reply

      I just used embryo glue on my frozen embryo.

  • pratibha
    Posted at 07:16h, 28 March Reply

    three cycles failed, embryo glue used fourth cycle. i want two know the success rate.

    • xyz
      Posted at 09:22h, 06 February Reply

      hi pratibha did embryo glue worked?????

  • pratibha
    Posted at 07:16h, 28 March Reply

    three cycles failed, embryo glue used fourth cycle. i want two know the success rate.

    • xyz
      Posted at 09:22h, 06 February Reply

      hi pratibha did embryo glue worked?????

  • BB
    Posted at 21:32h, 31 October Reply

    Can embryo glue be used as well as / alongside assisted hatching

  • BB
    Posted at 21:32h, 31 October Reply

    Can embryo glue be used as well as / alongside assisted hatching

  • Tati
    Posted at 20:11h, 10 March Reply

    Jennifer, did the glue work?

  • Tati
    Posted at 20:11h, 10 March Reply

    Jennifer, did the glue work?

  • Lina
    Posted at 02:46h, 16 March Reply

    Hello Jennifer, how did you go? did the glue work?

  • Lina
    Posted at 02:46h, 16 March Reply

    Hello Jennifer, how did you go? did the glue work?

  • Parisa
    Posted at 11:09h, 14 July Reply

    Can PRP ne used with hatching? (I.e. with laser-assisted hatching.)

  • Parisa
    Posted at 11:09h, 14 July Reply

    Can PRP ne used with hatching? (I.e. with laser-assisted hatching.)

  • Neliswa
    Posted at 12:13h, 20 November Reply

    My doc told me about embryo glue I don’t know anything about it how good it is? its going to be my third time doing the transfer.

  • Neliswa
    Posted at 12:13h, 20 November Reply

    My doc told me about embryo glue I don’t know anything about it how good it is? its going to be my third time doing the transfer.

  • Helga
    Posted at 11:36h, 26 March Reply

    I used Embryoglue during my first IVF transfer that was luckily successful. Whether this is due to the glue or other predispositions: who knows… With additionally 85 Euros (Germany), the costs were relatively low in my clinic, so we just went for it.
    Good luck to everyone!!

  • Helga
    Posted at 11:36h, 26 March Reply

    I used Embryoglue during my first IVF transfer that was luckily successful. Whether this is due to the glue or other predispositions: who knows… With additionally 85 Euros (Germany), the costs were relatively low in my clinic, so we just went for it.
    Good luck to everyone!!

  • Thatego
    Posted at 05:20h, 30 July Reply

    I just used embryo glue on my 2nd IVF. Awaiting for the result

    • Nicole
      Posted at 02:57h, 23 November Reply

      Was the glue a success?

  • Thatego
    Posted at 05:20h, 30 July Reply

    I just used embryo glue on my 2nd IVF. Awaiting for the result

    • Nicole
      Posted at 02:57h, 23 November Reply

      Was the glue a success?

    • Rachel ford
      Posted at 17:49h, 03 July Reply

      how much is embryo glue did it work

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