Estrogen – why do fertility patients need it?

Estrogen – why do fertility patients need it?

Estrogen, Why Do Fertility Patients Need It

Estrogen supplements during IVF? They’re sometimes prescribed. And they’re essential for women having donor eggs, donor embryos or frozen-embryo transfers. So why do some doctors, and the leaflets in the packs, scare fertility patients by claiming estrogen can be dangerous during pregnancy? It’s hardly the best news to give would-be mums. Here’s the truth about the role estrogen plays before and after fertility treatment.

Estrogen helps to grow and maintain your endometrial lining and sustain a pregnancy. It also helps your placenta function, boosts blood flow to your uterus and primes your body for breastfeeding. In an IVF cycle, FSH medication (e.g. Menopur and Gonal-f) creates multiple follicles. Estrogen production is then stimulated, causing the uterine lining to thicken.

By the time of your trigger shot, your estradiol levels are sky-high. But let’s face it, IVF medication upsets your body’s reproductive rhythms. Some research suggests estrogen supplements late in an IVF cycle improve pregnancy rates by stabilising the uterine lining. Other studies say it’s not needed. Get your doctor’s view.

Estrogen is certainly needed during fresh donor-egg cycles. Thickening your endometrial lining after your depot injection is mandatory. Depot injections down-regulate your ovaries, affecting your natural estrogen and progesterone production.

Oral estrogen pills (e.g Progynova and Estrofem), typically 6 mg per day, are the norm. Their start date forms part of the synchronisation between your and your donor’s cycle. A lining scan at least three days before your donor’s egg retrieval gives you time to adjust your estrogen intake.

If your lining is too thin, an extra 2 mg, or even 4 mg, may be suggested. Anything more than 10 mg daily may need Clexane support to thin your blood. Vaginal insertion of those extra pills is common: estradiol heads faster to your reproductive organs that way. Oral pills take the slow road via your liver.

You want a 7-mm lining, and ideally an 8-mm one, by your donor’s egg retrieval day. That’s the day you start your progesterone supplementation. Your lining won’t thicken any more after that.

So what’s the deal with estrogen and FETs? Once again, estrogen is needed to grow your lining and keep it thick. Because a reasonably high dose of estrogen is taken from day 2 of your cycle in an FET protocol, the hormone is a down-regulator and prevents ovulation. So your ovaries won’t interfere with the embryos you put back in.

But no ovarian activity means no natural estrogen. So, as for fresh donor eggs, you need artificial estrogen support until at least week nine of your pregnancy. Your clinic should tell you how to reduce your estrogen (and progesterone) from the 8-week mark or so.

Occasionally, patients just don’t respond well to estrogen pills. And women with a past history of cancer are sometimes told not to take them. In this case, embryo transfer during a natural-cycle FET may be best.

You’ll take no estrogens at all from the start of your natural bleed. Then you’ll have a scan around day 10 to see if your body’s natural estrogen has plumped up your lining sufficiently. If it has, and if we see good natural follicle growth, you’ll take a trigger shot to disperse the follicles and start your progesterone support a few days later. Embryo transfer will be five days after that.

Estrogen pills are commonly dispensed as Estrofem, Progynova, Provames, Climaval, Estrace and Estrimax. Patches include Estraderm and Estrahexal. A combination of pills and patches is sometimes prescribed to patients with ‘lazy’ linings.

We’ve also seen more use of estrogen gel by our clinic in recent years. For fertility patients, a 2018 study found that estrogen gel enhanced ongoing pregnancy and live birth rates compared to estrogen pills. And a 2020 study saw better endometrial thickness and fewer side effects. We predict oestrogel will be used more routinely by clinics in the future.

As for side effects, expect a few – particularly if you take your estrogen orally. Mild symptoms include headaches, nausea, fluid retention, tender breasts, irritability and mild depression.

A very small number of women risk more serious problems like chronic insomnia, stroke, blood clots and even ovarian cancer. But this is rare. For most women, estrogen has positive effects. And for fertility cycles, it’s the gateway to a successful pregnancy.

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102 Comments
  • Nivedita sharma
    Posted at 05:37h, 28 June Reply

    Nicely explained

  • Nivedita sharma
    Posted at 05:37h, 28 June Reply

    Nicely explained

  • Shaiia
    Posted at 06:39h, 28 December Reply

    Thank you.
    This is clearly explained and really cleared out any worries I had.

  • Shaiia
    Posted at 06:39h, 28 December Reply

    Thank you.
    This is clearly explained and really cleared out any worries I had.

  • Catherine
    Posted at 10:51h, 03 January Reply

    Thanks – this has really helped me as I started taking progynova orally on 31/12 and my clinic has been closed for the holidays. Once they reopen tomorrow I’m going to request a not oral version, hopefully this will help with the headaches & tears!

  • Catherine
    Posted at 10:51h, 03 January Reply

    Thanks – this has really helped me as I started taking progynova orally on 31/12 and my clinic has been closed for the holidays. Once they reopen tomorrow I’m going to request a not oral version, hopefully this will help with the headaches & tears!

  • Emily
    Posted at 16:02h, 14 February Reply

    I am on fresh egg donor transfer cycle and I didnt have period for 4 months before the cycle. The doc put me on 75ml patches (every 72 hours) for 10 days, my lining has increased from 5.3mm (before patch) to 13mm and I still have to wait for another 10 days to have embryo transfer. I had thick lining history in the past so now the doc told me to change to use pill 2mg only a day. Does it sound correct? I had two failed egg donor cycles already and I had 15mm thickness first time and 21mm second time, my clinic still asked me to go ahead but failed, I never had three lines patterns and I am concerned if my endometrium is not good enough for implantation. I had done hysteroscopy nothing was found. I am confused if I should carry on with this cycle. Could please help? Many thanks

    • MamaA
      Posted at 19:18h, 20 May Reply

      Hi Emily.
      I’m sorry you have gone through so much. I see your post is from February. I’m just curious to know how things have gone for you? I hope all is well. And I still wishing you the best of luck.

  • Emily
    Posted at 16:02h, 14 February Reply

    I am on fresh egg donor transfer cycle and I didnt have period for 4 months before the cycle. The doc put me on 75ml patches (every 72 hours) for 10 days, my lining has increased from 5.3mm (before patch) to 13mm and I still have to wait for another 10 days to have embryo transfer. I had thick lining history in the past so now the doc told me to change to use pill 2mg only a day. Does it sound correct? I had two failed egg donor cycles already and I had 15mm thickness first time and 21mm second time, my clinic still asked me to go ahead but failed, I never had three lines patterns and I am concerned if my endometrium is not good enough for implantation. I had done hysteroscopy nothing was found. I am confused if I should carry on with this cycle. Could please help? Many thanks

    • MamaA
      Posted at 19:18h, 20 May Reply

      Hi Emily.
      I’m sorry you have gone through so much. I see your post is from February. I’m just curious to know how things have gone for you? I hope all is well. And I still wishing you the best of luck.

  • Besa
    Posted at 23:19h, 28 April Reply

    Hi, my doctor has subscribe me progynova 2mg, 3 times a day. I was reading the side effects and some of them was breast or ovarian cancer, stroke or heart attack. This has really scared me from start taking it and the doctor did not even explain this to me or did not even asked for my previous medical history. I saffer from panic attacks. Should I take them ot not?
    I am very scared of side effects. Thanks

    • Prof Bamigboye
      Posted at 07:26h, 30 April Reply

      It is only when a patient is consistently exposed to estrogen that the risk of endometrial cancer or cardiovascular side effect increase. Occasional exposure as the case in an FET cycle may not warrant panic. However you are correct that your doctor should have allayed your fear by pre -empting your question. Relax and continue your medication.

  • Besa
    Posted at 23:19h, 28 April Reply

    Hi, my doctor has subscribe me progynova 2mg, 3 times a day. I was reading the side effects and some of them was breast or ovarian cancer, stroke or heart attack. This has really scared me from start taking it and the doctor did not even explain this to me or did not even asked for my previous medical history. I saffer from panic attacks. Should I take them ot not?
    I am very scared of side effects. Thanks

    • Prof Bamigboye
      Posted at 07:26h, 30 April Reply

      It is only when a patient is consistently exposed to estrogen that the risk of endometrial cancer or cardiovascular side effect increase. Occasional exposure as the case in an FET cycle may not warrant panic. However you are correct that your doctor should have allayed your fear by pre -empting your question. Relax and continue your medication.

  • Kylie
    Posted at 10:42h, 09 May Reply

    Hi,

    I am on 6mg Estrofem a day which will continue the next 2 weeks until my next visit at the IVF clinic. I do however feel very sick from the pills. I have vomited 3 times today and feel very sick. Due to circumstances I cant get in contact with my IVF clinic. Is this normal and should I continue to take the pills – I really dont feel like taking anymore pills right now.

    Thanks

    • Jo
      Posted at 17:08h, 17 May Reply

      I’m on Progynova 6mg a day and I too thought that was what was making me so sick and asked my dr to switch me to the patches. However she says I’m at too delicate a stage to switch (9 weeks) so I’m having to resort to keeping taking it and taking anti sickness tablets instead. I have to say I really felt like the Progynova was the issue and my friends who used patches said they were never actually sick (whereas I’m vomiting violently twice each morning). yet another example of something I wish I had known BEFORE I started treatment as sounds like I could have gone onto patches if I had raised this earlier.

    • MamaA
      Posted at 19:14h, 20 May Reply

      Hi Kylie. I dont have an answer for that. I was on 6mg/day, and now I’m on 4mg/day of Estrace. I just wanted to tell you to hang in there and I hope all goes well for you during your transfer. I wish you the best and stay positive. Good luck.

  • Kylie
    Posted at 10:42h, 09 May Reply

    Hi,

    I am on 6mg Estrofem a day which will continue the next 2 weeks until my next visit at the IVF clinic. I do however feel very sick from the pills. I have vomited 3 times today and feel very sick. Due to circumstances I cant get in contact with my IVF clinic. Is this normal and should I continue to take the pills – I really dont feel like taking anymore pills right now.

    Thanks

    • Jo
      Posted at 17:08h, 17 May Reply

      I’m on Progynova 6mg a day and I too thought that was what was making me so sick and asked my dr to switch me to the patches. However she says I’m at too delicate a stage to switch (9 weeks) so I’m having to resort to keeping taking it and taking anti sickness tablets instead. I have to say I really felt like the Progynova was the issue and my friends who used patches said they were never actually sick (whereas I’m vomiting violently twice each morning). yet another example of something I wish I had known BEFORE I started treatment as sounds like I could have gone onto patches if I had raised this earlier.

    • MamaA
      Posted at 19:14h, 20 May Reply

      Hi Kylie. I dont have an answer for that. I was on 6mg/day, and now I’m on 4mg/day of Estrace. I just wanted to tell you to hang in there and I hope all goes well for you during your transfer. I wish you the best and stay positive. Good luck.

  • Mally
    Posted at 10:32h, 18 May Reply

    Thanks for sharing it very informative.

  • Mally
    Posted at 10:32h, 18 May Reply

    Thanks for sharing it very informative.

  • Olga
    Posted at 13:40h, 26 May Reply

    Thanks for explaining the side effects of estrogen. Make me feel much better that it is actually ” normal” the way your body sometimes feel.

  • Olga
    Posted at 13:40h, 26 May Reply

    Thanks for explaining the side effects of estrogen. Make me feel much better that it is actually ” normal” the way your body sometimes feel.

  • Thilani
    Posted at 09:32h, 06 June Reply

    I’m still breast feeding my baby boy who is 1year and 8 months old.. Will estradiol secreted through breast milk and affect my baby if I get it for FER

  • Thilani
    Posted at 09:32h, 06 June Reply

    I’m still breast feeding my baby boy who is 1year and 8 months old.. Will estradiol secreted through breast milk and affect my baby if I get it for FER

  • Ana
    Posted at 14:23h, 07 June Reply

    I’m still breast feeding my baby who is 1year old. Will estradiol affect my baby if I get 6mg/daily?

  • Ana
    Posted at 14:23h, 07 June Reply

    I’m still breast feeding my baby who is 1year old. Will estradiol affect my baby if I get 6mg/daily?

  • Sue
    Posted at 20:12h, 10 June Reply

    I start progynova 6mm daily and often 10 day my lyinig is 2m what can I used to help

    • Monica
      Posted at 01:48h, 16 June Reply

      Can I ask have you had any side effects to the progenova

  • Sue
    Posted at 20:12h, 10 June Reply

    I start progynova 6mm daily and often 10 day my lyinig is 2m what can I used to help

    • Monica
      Posted at 01:48h, 16 June Reply

      Can I ask have you had any side effects to the progenova

  • Maryam
    Posted at 08:58h, 31 July Reply

    Hi,

    I am due to have a FET on the 11.08.17. I am having this done overseas however I’ve took 12mg of estrofem for the first two days then 8 mg on day 3, then 2 mg on day 4 and then 6 mg therefore. The doctor did not prescribe me 12mg at once I made the mistake of taking 6 tablets instead of 6mg. I am still planning on going ahead with the transfer. Anybody with any such experience of a high dosage at the beginning? Should I be scard?

  • Maryam
    Posted at 08:58h, 31 July Reply

    Hi,

    I am due to have a FET on the 11.08.17. I am having this done overseas however I’ve took 12mg of estrofem for the first two days then 8 mg on day 3, then 2 mg on day 4 and then 6 mg therefore. The doctor did not prescribe me 12mg at once I made the mistake of taking 6 tablets instead of 6mg. I am still planning on going ahead with the transfer. Anybody with any such experience of a high dosage at the beginning? Should I be scard?

  • Zelina
    Posted at 19:16h, 24 August Reply

    Hi, I’m pregnant and have been asked to take 2mg of Progynova twice a day. We conceived through IUI. Does anyone know if it’s recommended to continue after pregnancy? I keep reading information that we should not take it if you’re pregnant. Any advice would be great. Thanks

    • Omolara
      Posted at 20:30h, 03 January Reply

      Hi, pls for how many days did u took the progynova before confirmation of pregnancy

  • Zelina
    Posted at 19:16h, 24 August Reply

    Hi, I’m pregnant and have been asked to take 2mg of Progynova twice a day. We conceived through IUI. Does anyone know if it’s recommended to continue after pregnancy? I keep reading information that we should not take it if you’re pregnant. Any advice would be great. Thanks

    • Omolara
      Posted at 20:30h, 03 January Reply

      Hi, pls for how many days did u took the progynova before confirmation of pregnancy

  • Tanji
    Posted at 17:58h, 16 September Reply

    Hi I have been taking estradiol 2mg since my IVF Transfer. I have cramps and tender breast. I was hoping that this was a sign that I am pregnant. Can someone help me. I go for my 2 weeks test on the 19th to see if I am. Could these just be symptoms?

    • DianaK
      Posted at 13:45h, 10 October Reply

      How did it go?
      I am currently on my 2W wait period as well and I am experiencing the same symptoms, but
      I read that they could be due the estradiol and progesterone. They both have similar side effects and could be the same as pregnancy symptoms.

    • ruhi
      Posted at 18:08h, 11 November Reply

      donot worry n dnt keep guessing whtr u vil get ur prriod or u r pregnanat..because both symptoms r d same…so just relax n enjoy ur self n be happy..

  • Tanji
    Posted at 17:58h, 16 September Reply

    Hi I have been taking estradiol 2mg since my IVF Transfer. I have cramps and tender breast. I was hoping that this was a sign that I am pregnant. Can someone help me. I go for my 2 weeks test on the 19th to see if I am. Could these just be symptoms?

    • DianaK
      Posted at 13:45h, 10 October Reply

      How did it go?
      I am currently on my 2W wait period as well and I am experiencing the same symptoms, but
      I read that they could be due the estradiol and progesterone. They both have similar side effects and could be the same as pregnancy symptoms.

    • ruhi
      Posted at 18:08h, 11 November Reply

      donot worry n dnt keep guessing whtr u vil get ur prriod or u r pregnanat..because both symptoms r d same…so just relax n enjoy ur self n be happy..

  • Shikha
    Posted at 05:54h, 28 September Reply

    I had my FET on 23rd Sept.. doc prescribed me 4mg PROGYNOVA thrice a day, duphaston 2mg twice a day, Susten- 400 vaginal BD.. also sustem 100 mg inj alternate day… moreover taking folvite & ecospirin once daily…Need to have 2ww for beta HCG… NO symptoms of pregnancy till now, is it good or not good ?

    • vishali
      Posted at 17:06h, 17 February Reply

      Heyy Hii i m going through same phase had my Fet on 11th Feb n my doc suggested same Medicn which u hav told Plzz let me know wat happen to u I mean u got positive or???

    • Andy
      Posted at 13:35h, 10 October Reply

      Hi..i am prescribed with the same meds. I am under 2ww. What is your outcome?

  • Shikha
    Posted at 05:54h, 28 September Reply

    I had my FET on 23rd Sept.. doc prescribed me 4mg PROGYNOVA thrice a day, duphaston 2mg twice a day, Susten- 400 vaginal BD.. also sustem 100 mg inj alternate day… moreover taking folvite & ecospirin once daily…Need to have 2ww for beta HCG… NO symptoms of pregnancy till now, is it good or not good ?

    • vishali
      Posted at 17:06h, 17 February Reply

      Heyy Hii i m going through same phase had my Fet on 11th Feb n my doc suggested same Medicn which u hav told Plzz let me know wat happen to u I mean u got positive or???

    • Andy
      Posted at 13:35h, 10 October Reply

      Hi..i am prescribed with the same meds. I am under 2ww. What is your outcome?

  • Chloe O'Connor
    Posted at 10:34h, 19 November Reply

    I am taking 6mg of progynova per day for a FET. During yesterday, day 3, I developed abdominal pain. I thought it would dissipate overnight but I am still in pain this morning. Any comments appreciated. Thanks

  • Chloe O'Connor
    Posted at 10:34h, 19 November Reply

    I am taking 6mg of progynova per day for a FET. During yesterday, day 3, I developed abdominal pain. I thought it would dissipate overnight but I am still in pain this morning. Any comments appreciated. Thanks

  • Sana
    Posted at 06:40h, 22 November Reply

    Hi
    We are supposed to have embryo transfer in 3 days
    My wife is currently taken 4 tabs of estrofem per day the thing is she took it today 8 hours earlier!!
    Se tried to vomit and no pill came out just some water
    Plz help what to do?

  • Sana
    Posted at 06:40h, 22 November Reply

    Hi
    We are supposed to have embryo transfer in 3 days
    My wife is currently taken 4 tabs of estrofem per day the thing is she took it today 8 hours earlier!!
    Se tried to vomit and no pill came out just some water
    Plz help what to do?

  • Farah
    Posted at 09:41h, 25 November Reply

    Hi, I just finish progynova, ovaries are resting, no cysts and the endometrium is 5 mm, good news i will start tomorrow the stimulation. However, last night i have small cramps, is it normal?

  • Farah
    Posted at 09:41h, 25 November Reply

    Hi, I just finish progynova, ovaries are resting, no cysts and the endometrium is 5 mm, good news i will start tomorrow the stimulation. However, last night i have small cramps, is it normal?

  • ss
    Posted at 15:39h, 20 March Reply

    On successful IVF OD(at present) 6 weeks,doctor have told to continue for 3 more weeks & then to stop,what side effect I can expect on stopping?

  • ss
    Posted at 15:39h, 20 March Reply

    On successful IVF OD(at present) 6 weeks,doctor have told to continue for 3 more weeks & then to stop,what side effect I can expect on stopping?

  • Shah
    Posted at 14:53h, 09 April Reply

    I have gone through ivf cycle with donar eggs and it is positive. My doctor advised me to take estradiol 24 mg daily but by mistake I was taking 12 mg daily. Just today I came to know (6 week 6 days) pregnant. I am worried and afraid will it harm my fetus.

    • Derv
      Posted at 18:27h, 25 May Reply

      I’ve been taking on ovreena 30mg and now have been given progynova 2mg daily. I’m wondering if the dosage is low. I’m also taking vitamins b12 1000mg of fish oil clonfolic & soya isoflavins . I have not been given a date for fet yet. I’m worried I’m not getting enough info from my overseas clinic

  • Shah
    Posted at 14:53h, 09 April Reply

    I have gone through ivf cycle with donar eggs and it is positive. My doctor advised me to take estradiol 24 mg daily but by mistake I was taking 12 mg daily. Just today I came to know (6 week 6 days) pregnant. I am worried and afraid will it harm my fetus.

    • Derv
      Posted at 18:27h, 25 May Reply

      I’ve been taking on ovreena 30mg and now have been given progynova 2mg daily. I’m wondering if the dosage is low. I’m also taking vitamins b12 1000mg of fish oil clonfolic & soya isoflavins . I have not been given a date for fet yet. I’m worried I’m not getting enough info from my overseas clinic

  • Vna
    Posted at 22:54h, 09 April Reply

    Ii am on progynova 2 and on day 12 i was suggested for TVS but i started bleeding.

  • Vna
    Posted at 22:54h, 09 April Reply

    Ii am on progynova 2 and on day 12 i was suggested for TVS but i started bleeding.

  • Kimmy jamaica
    Posted at 19:40h, 04 October Reply

    I’m 4 weeks pregnant through IVF first attempt,
    However I’m on progynova 2 mg , 3 per day ,
    In my 3rd week I started spotting and StI’ll is .Sometimes my joints hurt and get really weak ,
    at times I get cramping in the pelvic ..

    Has anyone experienced this ?

    • Su
      Posted at 03:27h, 29 October Reply

      Hi there!I had my son thru IVF.I was spotting after 3th week,for a 2 weeks.My Dr.told me that is normal in some women .And joint pain is normsl as well.Your body is adjusting to pregnancy.I had shooting pain in my pelvic,it was expanding.
      Good luck

  • Kimmy jamaica
    Posted at 19:40h, 04 October Reply

    I’m 4 weeks pregnant through IVF first attempt,
    However I’m on progynova 2 mg , 3 per day ,
    In my 3rd week I started spotting and StI’ll is .Sometimes my joints hurt and get really weak ,
    at times I get cramping in the pelvic ..

    Has anyone experienced this ?

    • Su
      Posted at 03:27h, 29 October Reply

      Hi there!I had my son thru IVF.I was spotting after 3th week,for a 2 weeks.My Dr.told me that is normal in some women .And joint pain is normsl as well.Your body is adjusting to pregnancy.I had shooting pain in my pelvic,it was expanding.
      Good luck

  • Barbara
    Posted at 11:40h, 10 October Reply

    Hi,hv been on progynova 2mg too prayers for a successful pregnancy.

  • Barbara
    Posted at 11:40h, 10 October Reply

    Hi,hv been on progynova 2mg too prayers for a successful pregnancy.

  • Janaki
    Posted at 15:01h, 16 October Reply

    Dear Dr.
    My last ivf cycle was failed and d14 after ET
    Was negative .dr said ct estrogen and progesterone for another 3 days and rpt test in after 3days .today 20th day also beta hcg was negative.
    Dear dr
    Can you explain after stopped homone therapy just can be ovulate(wich start yo grow with previous induction) prior to menstruation
    Thank you
    Janaki

  • Janaki
    Posted at 15:01h, 16 October Reply

    Dear Dr.
    My last ivf cycle was failed and d14 after ET
    Was negative .dr said ct estrogen and progesterone for another 3 days and rpt test in after 3days .today 20th day also beta hcg was negative.
    Dear dr
    Can you explain after stopped homone therapy just can be ovulate(wich start yo grow with previous induction) prior to menstruation
    Thank you
    Janaki

  • Byd
    Posted at 18:33h, 30 November Reply

    Hi I had my First IVF transfer with two embryos on Wednesday 28/11/2018, Today is my 2day ET but I don’t have any symptom can some help please or is it too early to complain?

    • Rosey
      Posted at 05:41h, 23 March Reply

      I did my EFT on 20/03/2019. First fresh cycle failed. Im on estrofem now 6mg. My test is on the 29th I can’t help it nerves are killing me. The last time I did not cope well with the negative result.

  • Byd
    Posted at 18:33h, 30 November Reply

    Hi I had my First IVF transfer with two embryos on Wednesday 28/11/2018, Today is my 2day ET but I don’t have any symptom can some help please or is it too early to complain?

    • Rosey
      Posted at 05:41h, 23 March Reply

      I did my EFT on 20/03/2019. First fresh cycle failed. Im on estrofem now 6mg. My test is on the 29th I can’t help it nerves are killing me. The last time I did not cope well with the negative result.

  • Annie
    Posted at 19:34h, 24 December Reply

    I’m on Progynova 2mg, 6mg a day and I am 9 weeks pregnant, however I am vomiting 6-7 times a day not only morning but anytime including midnight. I believe it is Progynova that is causing me vomitting so badly I can’t eat anything not even drink water. So I skipped one pill and missed second Progynova for a day then I could eat for dinner first time.. Can I take 4mg rather than 6mg a day instead? Otherwise my baby won’t have rnough nutrition as I vomit so badly..

    • Prabhnoor kaur
      Posted at 07:23h, 27 February Reply

      I am 3 weeks pregnant..doctor told me to have progynova even after pregnancy…is it safer to have it..I read many articles that it is not safe
      In early pregnancy….I am so worried…could u guide me pls

  • Annie
    Posted at 19:34h, 24 December Reply

    I’m on Progynova 2mg, 6mg a day and I am 9 weeks pregnant, however I am vomiting 6-7 times a day not only morning but anytime including midnight. I believe it is Progynova that is causing me vomitting so badly I can’t eat anything not even drink water. So I skipped one pill and missed second Progynova for a day then I could eat for dinner first time.. Can I take 4mg rather than 6mg a day instead? Otherwise my baby won’t have rnough nutrition as I vomit so badly..

    • Prabhnoor kaur
      Posted at 07:23h, 27 February Reply

      I am 3 weeks pregnant..doctor told me to have progynova even after pregnancy…is it safer to have it..I read many articles that it is not safe
      In early pregnancy….I am so worried…could u guide me pls

  • Stephani
    Posted at 11:14h, 12 February Reply

    I was on estradiol tablets for almost 2weeks due to FET preparation but I stop as the FET did not take place. However, I have been waiting for my period and is overdue for almost 13days. Please is it normal to have such a long delay after having stopping estradiol tablets?

    • Charlotte
      Posted at 08:34h, 26 April Reply

      I was just on Estrogen as well also to prepare for FET. On day 10 she said that everything looked good so far and to come back next week. A follicle was seen on Day 10. I could see it myself. Next appointment she told me it had to be canceled as the local hospital will not do FET on Easter !! Why didn’t they just tell me that from the start, so that I don’t take medications that I don’t need. Hang in there.

  • Stephani
    Posted at 11:14h, 12 February Reply

    I was on estradiol tablets for almost 2weeks due to FET preparation but I stop as the FET did not take place. However, I have been waiting for my period and is overdue for almost 13days. Please is it normal to have such a long delay after having stopping estradiol tablets?

    • Charlotte
      Posted at 08:34h, 26 April Reply

      I was just on Estrogen as well also to prepare for FET. On day 10 she said that everything looked good so far and to come back next week. A follicle was seen on Day 10. I could see it myself. Next appointment she told me it had to be canceled as the local hospital will not do FET on Easter !! Why didn’t they just tell me that from the start, so that I don’t take medications that I don’t need. Hang in there.

  • Chioma
    Posted at 15:59h, 19 February Reply

    I just had a hysteroscopy after the doctor said that my lining is thin. So he recommends progynova 2mg, two times a day for one month.

    • Shannon
      Posted at 23:25h, 22 November Reply

      Hi there,

      I just saw your post, I just had a hysterscopy and have to take 2mg estrace, I’m just curious did you end up getting pregnant and were you able to do a fet after? And if so how long

      Thanks for any advice I know this is an old comment

      Shannon

  • Chioma
    Posted at 15:59h, 19 February Reply

    I just had a hysteroscopy after the doctor said that my lining is thin. So he recommends progynova 2mg, two times a day for one month.

    • Shannon
      Posted at 23:25h, 22 November Reply

      Hi there,

      I just saw your post, I just had a hysterscopy and have to take 2mg estrace, I’m just curious did you end up getting pregnant and were you able to do a fet after? And if so how long

      Thanks for any advice I know this is an old comment

      Shannon

  • Esosa
    Posted at 20:51h, 29 March Reply

    Hi am taking Estradiol 2mg. My lining is now 6mm and I was advised to continue for another three days. My question is that what if my lining is over 8mm, would that be normal and will they still continue with the transfer.

  • Esosa
    Posted at 20:51h, 29 March Reply

    Hi am taking Estradiol 2mg. My lining is now 6mm and I was advised to continue for another three days. My question is that what if my lining is over 8mm, would that be normal and will they still continue with the transfer.

    • Misty
      Posted at 15:57h, 20 November Reply

      Hi, I know you posted this years ago but I just wanted to add a reply in case other readers are concerned about this too. Over 8mm is definitely ok and actually good as 7-8 is the baseline for lining. The thicker the better. When you get close to 40mm that is when you will be too thick and at risk of bleeding.

  • DELALI
    Posted at 10:57h, 31 March Reply

    I had my transfer of fresh egg donor egg on 22 of March 2019. Doc. Prescribed 2mg 3 times daily, progesterone injection 100mg a day and progesterone 400mg pessaries. I only have headaches, little tiredness,salivary mouth for a day or two. In fact am just as healthy as I went to do the IVF with donor eggs. No serious symptoms of pregnancy. It this normal.

  • DELALI
    Posted at 10:57h, 31 March Reply

    I had my transfer of fresh egg donor egg on 22 of March 2019. Doc. Prescribed 2mg 3 times daily, progesterone injection 100mg a day and progesterone 400mg pessaries. I only have headaches, little tiredness,salivary mouth for a day or two. In fact am just as healthy as I went to do the IVF with donor eggs. No serious symptoms of pregnancy. It this normal.

  • Sonal
    Posted at 11:36h, 24 December Reply

    I had egg donor ivf tranfer and got positive from 10th day of transfer i got started itching and redishness on my body so doctor advised me to stop progynova
    So can pregnancy grow naturally ..

  • Sonal
    Posted at 11:36h, 24 December Reply

    I had egg donor ivf tranfer and got positive from 10th day of transfer i got started itching and redishness on my body so doctor advised me to stop progynova
    So can pregnancy grow naturally ..

  • Tiya
    Posted at 15:49h, 10 January Reply

    Im in early pregnancy of 5 weeks . Doctor suggests me to take progynova 2mg twice a day as i was taking ovigyn D3 before conceiving. Is it safe to take the med.

  • Tiya
    Posted at 15:49h, 10 January Reply

    Im in early pregnancy of 5 weeks . Doctor suggests me to take progynova 2mg twice a day as i was taking ovigyn D3 before conceiving. Is it safe to take the med.

  • Mkm
    Posted at 02:43h, 01 June Reply

    Can i reduce my estrogen intake on my own wirhout letting doxtor know before transfer …

  • Mkm
    Posted at 02:43h, 01 June Reply

    Can i reduce my estrogen intake on my own wirhout letting doxtor know before transfer …

  • Bittu
    Posted at 18:03h, 24 July Reply

    I am trying to concieve.today is my 11 th dy and my egg size is 15mm and uterus lining is 6mm. Doc suggested me to intake 2mg estradiol valerate tablets thrice a day. Is it ok to intake thrice a day.(total 10 tab)

  • Jellen
    Posted at 23:25h, 11 March Reply

    Hi, I’ll be having an FET procedure by April, my period just started tonight, and it says on my protocol that I need to take the oestrogen tablet on the 2nd day of my cycle but unfortunately the medicine I ordered from Czech have not arrived today, it will be delivered on Monday but don’t know what time it will come, and this will mean that I have missed two days of my oestrogen pills. Will this affect my FET?

  • Ana
    Posted at 10:08h, 20 August Reply

    Hi. Thanks for the article, it’s very helpful. I wanted to find something about taking Estrofem before the day #1 of the cycle. My doctor prescribed it to me saying that it will help to prime my body for the IVF cycle, making the eggs being mature at the same time (so it has nothing to do with uterus line). But I need to taking them 1 week before my periods presumly starts. I may be pregnant without knowing (because I’m still trying to get pregnant naturally) and I’m afraid of the effects it may cause in this case.

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